2-{(1S*,2S*)-2-[(E)-(2,4-Dihydroxybenzylidene)amino]cyclohexyl}isoindoline-1,3-dione
نویسندگان
چکیده
In the title mol-ecule, C(21)H(20)N(2)O(4), the dihedral angle between the phenol ring and the isoindole-1,3-dione mean plane is 69.79 (6)°. The cyclo-hexane ring adopts a chair conformation. Weak inter-molecular O-H⋯O and O-H⋯N inter-actions feature as part of the crystal packing.
منابع مشابه
2-{(1R,2R)-2-[Bis(4-methylbenzyl)amino]cyclohexyl}isoindoline-1,3-dione
In the title mol-ecule, C(30)H(32)N(2)O(2), the two tolyl rings form dihedral angles of 65.8 (1) and 6.6 (1)° with the isoindole-1,3-dione mean plane. The cyclo-hexane ring adopts a chair conformation.
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In the title compound, C30H20N2O6·C2H6O·0.5H2O, the solvent water mol-ecule lies on a twofold rotation axis. The dihedral angle between the essentially planar isoindole ring systems [maximum deviations = 0.028 (1) and 0.022 (1) Å] is 47.12 (5)°. The dihedral angle between the benzene rings is 81.32 (7)°. In the crystal, the components are linked into a three-dimensional network via O-H⋯O hydrog...
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In the title compound, C(15)H(8)Cl(2)N(2)O(2), the mol-ecule adopts an E configuration about the central C=N double bond. The isoindoline ring is essentially planar, with a maximum deviation of 0.019 (2) Å. The dihedral angle between the isoindoline ring and the dichloro-substituted benzene ring is 6.54 (9)°. An intra-molecular C-H⋯O hydrogen bond occurs. A short Cl⋯Cl contact of 3.4027 (9) Å i...
متن کامل2-(2-Fluoro-4-hydroxybenzyl)isoindoline-1,3-dione
In the title compound, C(15)H(10)FNO(3), the dihedral angle between the isoindoline-1,3-dione and 3-fluoro-4-methyl-phenol groups is 86.88 (8)°. The isoindoline-1,3-dione fragment is almost planar, with an r.m.s. deviation of 0.0154 Å within the group. Inter-molecular C-H⋯O hydrogen bonds generate C(6) chains running parallel to the [010] direction.
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A green and convenient protocol is described for the preparation of E-1-(alkylamino)-3- (1,3-dioxoisoindolin-2-yl)-2-methyl-1-oxopropan-2-yl viaone-pot three-component reaction between 2-(2-oxopropyl)isoindoline-1,3-dione, an alkyl isocyanide and an E-cinnamic acid in water at room temperature. The methods used to follow the reactions are TLC and NMR, which indicated that there is no side produ...
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